6TL3

Crystal structure of an Estrogen Receptor alpha 8-mer phosphopeptide in complex with 14-3-3sigma stabilized by a Pyrrolidone1 derivative

Summary for 6TL3

• Entry DOI: 10.2210/pdb6tl3/pdb
• Related: 6TJM
• Descriptor: 14-3-3 protein sigma, Estrogen receptor, 5-[(2~{S},3~{R})-3-[(~{R})-azanyl(phenyl)methyl]-2-(4-nitrophenyl)-4,5-bis(oxidanylidene)pyrrolidin-1-yl]-2-oxidanyl-benzoic acid, ... (4 entities in total)
• Functional Keywords: estrogen receptor, 14-3-3, ppi, stabiliser, complex, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 27915.20

Authors

Andrei, S.A.,Bosica, F.,Ottmann, C.,O'Mahony, G. (deposition date: 2019-11-30, release date: 2020-04-29, Last modification date: 2024-01-24)

• Primary citation: Bosica, F.,Andrei, S.A.,Neves, J.F.,Brandt, P.,Gunnarsson, A.,Landrieu, I.,Ottmann, C.,O'Mahony, G.; Design of Drug-Like Protein-Protein Interaction Stabilizers Guided By Chelation-Controlled Bioactive Conformation Stabilization.; Chemistry, 26:7131-7139, 2020; PubMed: 32255539; DOI: 10.1002/chem.202001608

Experimental method

X-RAY DIFFRACTION (2.455 Å)