Summary for 6TKB
Entry DOI | 10.2210/pdb6tkb/pdb |
Descriptor | Chilob 7/4 H2 heavy chain C224S, Chilob 7/4 H2 kappa chain (3 entities in total) |
Functional Keywords | immunology, antibody, igg, igg2, immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 97125.93 |
Authors | Orr, C.M.,Fisher, H.,Tews, I. (deposition date: 2019-11-28, release date: 2021-06-09, Last modification date: 2024-01-31) |
Primary citation | Orr, C.M.,Fisher, H.,Yu, X.,Chan, C.H.,Gao, Y.,Duriez, P.J.,Booth, S.G.,Elliott, I.,Inzhelevskaya, T.,Mockridge, I.,Penfold, C.A.,Wagner, A.,Glennie, M.J.,White, A.L.,Essex, J.W.,Pearson, A.R.,Cragg, M.S.,Tews, I. Hinge disulfides in human IgG2 CD40 antibodies modulate receptor signaling by regulation of conformation and flexibility. Sci Immunol, 7:eabm3723-eabm3723, 2022 Cited by PubMed: 35857577DOI: 10.1126/sciimmunol.abm3723 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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