6TJM

Crystal structure of an Estrogen Receptor alpha 8-mer phosphopeptide in complex with 14-3-3sigma stabilized by Pyrrolidone1

6TJM の概要

• エントリーDOI: 10.2210/pdb6tjm/pdb
• 分子名称: 14-3-3 protein sigma, C-terminal phosphopeptide of human estrogen receptor alpha, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: estrogen receptor, 14-3-3, ppi, stabiliser, complex, signaling protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 27924.49

構造登録者

Andrei, S.A.,Bosica, F.,Ottmann, C.,O'Mahony, G. (登録日: 2019-11-26, 公開日: 2020-04-29, 最終更新日: 2024-01-24)

• 主引用文献: Bosica, F.,Andrei, S.A.,Neves, J.F.,Brandt, P.,Gunnarsson, A.,Landrieu, I.,Ottmann, C.,O'Mahony, G.; Design of Drug-Like Protein-Protein Interaction Stabilizers Guided By Chelation-Controlled Bioactive Conformation Stabilization.; Chemistry, 26:7131-7139, 2020; PubMed: 32255539; DOI: 10.1002/chem.202001608

実験手法

X-RAY DIFFRACTION (1.85 Å)