6TI9

Human transthyretin (TTR) complexed with (E)-3-(((3,5-dibromo-2-hydroxybenzylidene)amino)oxy)propanoic acid.

6TI9 の概要

• エントリーDOI: 10.2210/pdb6ti9/pdb
• 分子名称: Transthyretin, 3-[(~{E})-[3,5-bis(bromanyl)-2-oxidanyl-phenyl]methylideneamino]oxypropanoic acid, GLYCEROL, ... (5 entities in total)
• 機能のキーワード: transthyretin, ttr, inhibitor, complex, protein transport
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 28647.09

構造登録者

Ciccone, L.,Nencetti, S.,Orlandini, E.,Rossello, A.,Legrand, P.,Shepard, W. (登録日: 2019-11-22, 公開日: 2020-10-21, 最終更新日: 2024-01-24)

• 主引用文献: Ciccone, L.,Nencetti, S.,Tonali, N.,Fruchart-Gaillard, C.,Shepard, W.,Nuti, E.,Camodeca, C.,Rossello, A.,Orlandini, E.; Monoaryl derivatives as transthyretin fibril formation inhibitors: Design, synthesis, biological evaluation and structural analysis.; Bioorg.Med.Chem., 28:115673-115673, 2020; PubMed: 32828431; DOI: 10.1016/j.bmc.2020.115673

実験手法

X-RAY DIFFRACTION (1.45 Å)