6THZ

IRAK4 IN COMPLEX WITH inhibitor

6THZ の概要

• エントリーDOI: 10.2210/pdb6thz/pdb
• 分子名称: Interleukin-1 receptor-associated kinase 4, 7-fluoranyl-~{N}-[1-(2-methyl-2-azaspiro[3.3]heptan-6-yl)pyrazol-4-yl]-4-(1-methylcyclopropyl)oxy-6-(2-methylpyrimidin-5-yl)pyrido[3,2-d]pyrimidin-2-amine (3 entities in total)
• 機能のキーワード: irak4, kinase, inhibitor, cancer, signaling protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 70273.13

構造登録者

Xue, Y.,Aagaard, A.,Degorce, S.L. (登録日: 2019-11-21, 公開日: 2020-10-28, 最終更新日: 2024-05-01)

• 主引用文献: Degorce, S.L.,Aagaard, A.,Anjum, R.,Cumming, I.A.,Diene, C.R.,Fallan, C.,Johnson, T.,Leuchowius, K.J.,Orton, A.L.,Pearson, S.,Robb, G.R.,Rosen, A.,Scarfe, G.B.,Scott, J.S.,Smith, J.M.,Steward, O.R.,Terstiege, I.,Tucker, M.J.,Turner, P.,Wilkinson, S.D.,Wrigley, G.L.,Xue, Y.; Improving metabolic stability and removing aldehyde oxidase liability in a 5-azaquinazoline series of IRAK4 inhibitors.; Bioorg.Med.Chem., 28:115815-115815, 2020; PubMed: 33091850; DOI: 10.1016/j.bmc.2020.115815

実験手法

X-RAY DIFFRACTION (2.38 Å)