6THI

Solution structure of MeuNaTxalpha-1 toxin from Mesobuthus Eupeus

6THI の概要

• エントリーDOI: 10.2210/pdb6thi/pdb
• NMR情報: BMRB: 34453
• 分子名称: Sodium channel neurotoxin MeuNaTxalpha-1 (1 entity in total)
• 機能のキーワード: toxin, alpha-toxin, sodium channel blocker
• 由来する生物種: Mesobuthus eupeus (Lesser Asian scorpion)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 7196.15

構造登録者

Mineev, K.S.,Kuzmenkov, A.I.,Khusainov, G.A.,Arseniev, A.S.,Vassilevski, A.A. (登録日: 2019-11-20, 公開日: 2020-12-02, 最終更新日: 2024-10-16)

主引用文献

Mineev, K.S.,Kuzmenkov, A.I.,Arseniev, A.S.,Vassilevski, A.A.
Structure of MeuNaTx alpha-1 toxin from scorpion venom highlights the importance of the nest motif.
Proteins, 2021

PubMed Abstract: Old world scorpions produce an abundance of toxins called α-NaTx, which interfere with the fast inactivation of voltage-gated sodium channels. Their selectivity to channels of mammals or insects depends on a part of toxin named the specificity module. We report here the spatial structure of a major and broadly active toxin MeuNaTxα-1 from the venom of Mesobuthus eupeus. Notably, its specificity module is markedly different from other α-NaTx with known 3D structure. Close inspection shows that its conformation is a result of an interplay between protein motifs such as the nest and niche, which eventually shape α-NaTx structural diversity.

PubMed: 33713480
DOI: 10.1002/prot.26074

実験手法

SOLUTION NMR