6THC

Crystal structure of Mycobacterium smegmatis CoaB in complex with CTP and (4-hydroxyphenyl)(2,3,4-trihydroxyphenyl)methanone

6THC の概要

• エントリーDOI: 10.2210/pdb6thc/pdb
• 分子名称: Coenzyme A biosynthesis bifunctional protein CoaBC, CYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, ... (6 entities in total)
• 機能のキーワード: coabc, bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate-cysteine ligase, phosphopantothenate-cysteine ligase, phosphopantothenoylcysteine decarboxylase, phosphopantothenoylcysteine synthetase, ligase
• 由来する生物種: Mycolicibacterium smegmatis
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 102843.32

構造登録者

Mendes, V.,Blaszczyk, M.,Bryant, O.,Cory-Wright, J.,Blundell, T.L. (登録日: 2019-11-19, 公開日: 2020-11-25, 最終更新日: 2024-01-24)

• 主引用文献: Mendes, V.,Green, S.R.,Evans, J.C.,Hess, J.,Blaszczyk, M.,Spry, C.,Bryant, O.,Cory-Wright, J.,Chan, D.S.,Torres, P.H.M.,Wang, Z.,Nahiyaan, N.,O'Neill, S.,Damerow, S.,Post, J.,Bayliss, T.,Lynch, S.L.,Coyne, A.G.,Ray, P.C.,Abell, C.,Rhee, K.Y.,Boshoff, H.I.M.,Barry, C.E.,Mizrahi, V.,Wyatt, P.G.,Blundell, T.L.; Inhibiting Mycobacterium tuberculosis CoaBC by targeting an allosteric site.; Nat Commun, 12:143-143, 2021; PubMed: 33420031; DOI: 10.1038/s41467-020-20224-x

実験手法

X-RAY DIFFRACTION (2.033 Å)