6TGG

scFv-1SM3 in complex with glycopeptide containing an sp2-imino sugar

Summary for 6TGG

• Entry DOI: 10.2210/pdb6tgg/pdb
• Descriptor: ScFv_SM3, Mucin-1, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: antibody, scfv, antigen tn, iminosugar, anti cancer vaccine, conformational analysis, antitumor protein
• Biological source: Mus musculus (House mouse); More
• Total number of polymer chains: 2
• Total formula weight: 26893.54

Authors

Bermejo, I.A.,Navo, C.D.,Castro-Lopez, J.,Samchez-Fernandez, E.M.,Guerreiro, A.,Avenoza, A.,Busto, J.H.,Garcia-Martin, F.,Nishimura, S.I.,Garcia-Fernandez, J.M.,Ortiz-Mellet, C.,Bernardes, G.J.L.,Hurtado-Guerrero, R.,Peregrina, J.M.,Corzana, F. (deposition date: 2019-11-15, release date: 2020-04-08, Last modification date: 2024-01-24)

• Primary citation: Bermejo, I.A.,Navo, C.D.,Castro-Lopez, J.,Guerreiro, A.,Jimenez-Moreno, E.,Sanchez Fernandez, E.M.,Garcia-Martin, F.,Hinou, H.,Nishimura, S.I.,Garcia Fernandez, J.M.,Mellet, C.O.,Avenoza, A.,Busto, J.H.,Bernardes, G.J.L.,Hurtado-Guerrero, R.,Peregrina, J.M.,Corzana, F.; Synthesis, conformational analysis and in vivo assays of an anti-cancer vaccine that features an unnatural antigen based on an sp 2 -iminosugar fragment.; Chem Sci, 11:3996-4006, 2020; PubMed: 34122869; DOI: 10.1039/c9sc06334j

Experimental method

X-RAY DIFFRACTION (2 Å)