6TE1
Structure of the KDM1A/CoREST complex with the inhibitor 2-[3-{4-chloro-3-[(4-chlorophenyl)ethynyl]phenyl}-1-(3-morpholin-4-ylpropyl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]-2-oxoethanol
Summary for 6TE1
Entry DOI | 10.2210/pdb6te1/pdb |
Descriptor | Lysine-specific histone demethylase 1A, REST corepressor 1, 5-[4-cyclobutyl-1-[2-(4-piperidin-4-yloxyphenoxy)ethyl]imidazol-2-yl]-4-methyl-thieno[3,2-b]pyrrole, ... (6 entities in total) |
Functional Keywords | histone demethylase, inhibitor, complex, oxidoreductase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 148312.70 |
Authors | Pasqualato, S.,Cecatiello, V. (deposition date: 2019-11-11, release date: 2020-06-03, Last modification date: 2024-01-24) |
Primary citation | Romussi, A.,Cappa, A.,Vianello, P.,Brambillasca, S.,Cera, M.R.,Dal Zuffo, R.,Faga, G.,Fattori, R.,Moretti, L.,Trifiro, P.,Villa, M.,Vultaggio, S.,Cecatiello, V.,Pasqualato, S.,Dondio, G.,So, C.W.E.,Minucci, S.,Sartori, L.,Varasi, M.,Mercurio, C. Discovery of Reversible Inhibitors of KDM1A Efficacious in Acute Myeloid Leukemia Models. Acs Med.Chem.Lett., 11:754-759, 2020 Cited by PubMed: 32435381DOI: 10.1021/acsmedchemlett.9b00604 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.11 Å) |
Structure validation
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