6TDF

Crystal structure of Aspergillus fumigatus Glucosamine-6-phosphate N-acetyltransferase 1 in complex with compound 3

Summary for 6TDF

Entry DOI	10.2210/pdb6tdf/pdb
Descriptor	Glucosamine 6-phosphate N-acetyltransferase, ACETYL COENZYME *A, 2-[[3,5-bis(chloranyl)-4-(4~{H}-1,2,4-triazol-3-yl)phenyl]-(2-hydroxyethyl)amino]ethanol, ... (5 entities in total)
Functional Keywords	fragment screening, anti fungal, aspergillus fumigatus, inhibitor, transferase
Biological source	Aspergillus fumigatus Af293
Total number of polymer chains	1
Total formula weight	22512.99
Authors	Raimi, O.G.,Stanley, M.,Lockhart, D. (deposition date: 2019-11-08, release date: 2020-04-29, Last modification date: 2024-01-24)
Primary citation	Lockhart, D.E.A.,Stanley, M.,Raimi, O.G.,Robinson, D.A.,Boldovjakova, D.,Squair, D.R.,Ferenbach, A.T.,Fang, W.,van Aalten, D.M.F. Targeting a critical step in fungal hexosamine biosynthesis. J.Biol.Chem., 295:8678-8691, 2020 Cited by PubMed: 32341126 DOI: 10.1074/jbc.RA120.012985 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.01 Å)

Structure validation