6TD9

X-ray structure of mature PA1624 from Pseudomonas aeruginosa PAO1

6TD9 の概要

• エントリーDOI: 10.2210/pdb6td9/pdb
• 分子名称: PA1624, 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (5 entities in total)
• 機能のキーワード: periplasmic protein, unique fold, unknown function
• 由来する生物種: Pseudomonas aeruginosa PAO1
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 55990.68

構造登録者

Feiler, C.G.,Blankenfeldt, W. (登録日: 2019-11-08, 公開日: 2019-12-04, 最終更新日: 2024-11-13)

主引用文献

Feiler, C.G.,Weiss, M.S.,Blankenfeldt, W.
The hypothetical periplasmic protein PA1624 from Pseudomonas aeruginosa folds into a unique two-domain structure.
Acta Crystallogr.,Sect.F, 76:609-615, 2020

PubMed Abstract: The crystal structure of the 268-residue periplasmic protein PA1624 from the opportunistic pathogen Pseudomonas aeruginosa PAO1 was determined to high resolution using the Se-SAD method for initial phasing. The protein was found to be monomeric and the structure consists of two domains, domains 1 and 2, comprising residues 24-184 and 185-268, respectively. The fold of these domains could not be predicted even using state-of-the-art prediction methods, and similarity searches revealed only a very distant homology to known structures, namely to Mog1p/PsbP-like and OmpA-like proteins for the N- and C-terminal domains, respectively. Since PA1624 is only present in an important human pathogen, its unique structure and periplasmic location render it a potential drug target. Consequently, the results presented here may open new avenues for the discovery and design of antibacterial drugs.

PubMed: 33263573
DOI: 10.1107/S2053230X20014612

実験手法

X-RAY DIFFRACTION (1.96 Å)