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6TBE

LC3A in complex with (3R,4S,5R,6R)-5-hydroxy-6-((4-hydroxy-3-(4-hydroxy-3-isopentylbenzamido)-8-methyl-2-oxo-2H-chromen-7-yl)oxy)-3-methoxy-2,2-dimethyltetrahydro-2H-pyran-4-yl carbamate

Summary for 6TBE
Entry DOI10.2210/pdb6tbe/pdb
DescriptorMicrotubule-associated proteins 1A/1B light chain 3A, NOVOBIOCIN, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywordsinhibitor, complex, lc3a, autophagy, hydrolase
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight14769.92
Authors
Kramer, J.S.,Pogoryelov, D.,Hartmann, M.,Chaikuad, A.,Proschak, E. (deposition date: 2019-11-01, release date: 2020-11-18, Last modification date: 2024-01-24)
Primary citationHartmann, M.,Huber, J.,Kramer, J.S.,Heering, J.,Pietsch, L.,Stark, H.,Odadzic, D.,Bischoff, I.,Furst, R.,Schroder, M.,Akutsu, M.,Chaikuad, A.,Dotsch, V.,Knapp, S.,Biondi, R.M.,Rogov, V.V.,Proschak, E.
Demonstrating Ligandability of the LC3A and LC3B Adapter Interface.
J.Med.Chem., 64:3720-3746, 2021
Cited by
PubMed: 33769048
DOI: 10.1021/acs.jmedchem.0c01564
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.67008040045 Å)
Structure validation

221051

数据于2024-06-12公开中

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