6TBE

LC3A in complex with (3R,4S,5R,6R)-5-hydroxy-6-((4-hydroxy-3-(4-hydroxy-3-isopentylbenzamido)-8-methyl-2-oxo-2H-chromen-7-yl)oxy)-3-methoxy-2,2-dimethyltetrahydro-2H-pyran-4-yl carbamate

Summary for 6TBE

Entry DOI	10.2210/pdb6tbe/pdb
Descriptor	Microtubule-associated proteins 1A/1B light chain 3A, NOVOBIOCIN, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	inhibitor, complex, lc3a, autophagy, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	14769.92
Authors	Kramer, J.S.,Pogoryelov, D.,Hartmann, M.,Chaikuad, A.,Proschak, E. (deposition date: 2019-11-01, release date: 2020-11-18, Last modification date: 2024-01-24)
Primary citation	Hartmann, M.,Huber, J.,Kramer, J.S.,Heering, J.,Pietsch, L.,Stark, H.,Odadzic, D.,Bischoff, I.,Furst, R.,Schroder, M.,Akutsu, M.,Chaikuad, A.,Dotsch, V.,Knapp, S.,Biondi, R.M.,Rogov, V.V.,Proschak, E. Demonstrating Ligandability of the LC3A and LC3B Adapter Interface. J.Med.Chem., 64:3720-3746, 2021 Cited by PubMed: 33769048 DOI: 10.1021/acs.jmedchem.0c01564 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.67008040045 Å)

Structure validation