6TBE

LC3A in complex with (3R,4S,5R,6R)-5-hydroxy-6-((4-hydroxy-3-(4-hydroxy-3-isopentylbenzamido)-8-methyl-2-oxo-2H-chromen-7-yl)oxy)-3-methoxy-2,2-dimethyltetrahydro-2H-pyran-4-yl carbamate

6TBE の概要

• エントリーDOI: 10.2210/pdb6tbe/pdb
• 分子名称: Microtubule-associated proteins 1A/1B light chain 3A, NOVOBIOCIN, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: inhibitor, complex, lc3a, autophagy, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 14769.92

構造登録者

Kramer, J.S.,Pogoryelov, D.,Hartmann, M.,Chaikuad, A.,Proschak, E. (登録日: 2019-11-01, 公開日: 2020-11-18, 最終更新日: 2024-01-24)

• 主引用文献: Hartmann, M.,Huber, J.,Kramer, J.S.,Heering, J.,Pietsch, L.,Stark, H.,Odadzic, D.,Bischoff, I.,Furst, R.,Schroder, M.,Akutsu, M.,Chaikuad, A.,Dotsch, V.,Knapp, S.,Biondi, R.M.,Rogov, V.V.,Proschak, E.; Demonstrating Ligandability of the LC3A and LC3B Adapter Interface.; J.Med.Chem., 64:3720-3746, 2021; PubMed: 33769048; DOI: 10.1021/acs.jmedchem.0c01564

実験手法

X-RAY DIFFRACTION (1.67008040045 Å)