6TBB

Crystal structure of S. aureus FabI in complex with NADPH and kalimantacin A (batumin)

6TBB の概要

• エントリーDOI: 10.2210/pdb6tbb/pdb
• 関連するPDBエントリー: 6TBC
• 分子名称: Enoyl-[acyl-carrier-protein] reductase [NADPH], NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Kalimantacin, ... (4 entities in total)
• 機能のキーワード: enoyl-[acyl carrier protein] reductase, fatty acid biosynthesis, rossmann fold, short-chain dehydrogenase/reductase, biosynthetic protein
• 由来する生物種: Staphylococcus aureus
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 238075.17

構造登録者

Fage, C.D.,Masschelein, J. (登録日: 2019-11-01, 公開日: 2020-04-01, 最終更新日: 2024-01-24)

• 主引用文献: Fage, C.D.,Lathouwers, T.,Vanmeert, M.,Gao, L.J.,Vrancken, K.,Lammens, E.M.,Weir, A.N.M.,Degroote, R.,Cuppens, H.,Kosol, S.,Simpson, T.J.,Crump, M.P.,Willis, C.L.,Herdewijn, P.,Lescrinier, E.,Lavigne, R.,Anne, J.,Masschelein, J.; The Kalimantacin Polyketide Antibiotics Inhibit Fatty Acid Biosynthesis in Staphylococcus aureus by Targeting the Enoyl-Acyl Carrier Protein Binding Site of FabI.; Angew.Chem.Int.Ed.Engl., 59:10549-10556, 2020; PubMed: 32208550; DOI: 10.1002/anie.201915407

実験手法

X-RAY DIFFRACTION (2.45 Å)