Summary for 6TAV
Entry DOI | 10.2210/pdb6tav/pdb |
Descriptor | Alpha-2-macroglobulin, alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total) |
Functional Keywords | peptidase inhibitor, proteinase inhibitor, zn-and cu-binding protein, cytokine binding, hormone binding, protein binding, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 666202.72 |
Authors | Gomis-Ruth, F.X.,Duquerroy, S.,Trapani, S.,Marrero, A.,Goulas, T.,Guevara, T.,Andersen, G.A.,Sottrup-Jensen, L.,Navaza, J. (deposition date: 2019-10-30, release date: 2021-05-12, Last modification date: 2024-01-24) |
Primary citation | Luque, D.,Goulas, T.,Mata, C.P.,Mendes, S.R.,Gomis-Ruth, F.X.,Caston, J.R. Cryo-EM structures shows the mechanistic basis of pan-peptidase inhibition by human alpha2-macroglobulin Proc.Natl.Acad.Sci.USA, 2022 |
Experimental method | X-RAY DIFFRACTION (4.2 Å) |
Structure validation
Download full validation report