6TAV

Crystal structure of endopeptidase-induced alpha2-macroglobulin

「4ACQ」から置き換えられました

6TAV の概要

• エントリーDOI: 10.2210/pdb6tav/pdb
• 分子名称: Alpha-2-macroglobulin, alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: peptidase inhibitor, proteinase inhibitor, zn-and cu-binding protein, cytokine binding, hormone binding, protein binding, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 666202.72

構造登録者

Gomis-Ruth, F.X.,Duquerroy, S.,Trapani, S.,Marrero, A.,Goulas, T.,Guevara, T.,Andersen, G.A.,Sottrup-Jensen, L.,Navaza, J. (登録日: 2019-10-30, 公開日: 2021-05-12, 最終更新日: 2024-01-24)

• 主引用文献: Luque, D.,Goulas, T.,Mata, C.P.,Mendes, S.R.,Gomis-Ruth, F.X.,Caston, J.R.; Cryo-EM structures shows the mechanistic basis of pan-peptidase inhibition by human alpha2-macroglobulin; Proc.Natl.Acad.Sci.USA, 2022

実験手法

X-RAY DIFFRACTION (4.2 Å)