6T9V
Bovine Trypsin in complex with the synthetic inhibitor (S)-3-(3-(4-(3-(tert-butyl)ureido)piperidin-1-yl)-2-((3'-fluoro-4'-(hydroxymethyl)-[1,1'-biphenyl])-3-sulfonamido)-3-oxopropyl)benzimidamide (MI-1904)
Summary for 6T9V
| Entry DOI | 10.2210/pdb6t9v/pdb |
| Descriptor | Cationic Trypsin, trifluoroacetic acid, DIMETHYL SULFOXIDE, ... (6 entities in total) |
| Functional Keywords | trypsine, complex, ligand, hydrolase |
| Biological source | Bos taurus |
| Total number of polymer chains | 1 |
| Total formula weight | 26769.34 |
| Authors | Merkl, S.,Keils, A.,Mueller, J.M.,Pilgram, O.,Steinmetzer, T. (deposition date: 2019-10-28, release date: 2020-11-18, Last modification date: 2024-01-24) |
| Primary citation | Pilgram, O.,Keils, A.,Benary, G.E.,Muller, J.,Merkl, S.,Ngaha, S.,Huber, S.,Chevillard, F.,Harbig, A.,Magdolen, V.,Heine, A.,Bottcher-Friebertshauser, E.,Steinmetzer, T. Improving the selectivity of 3-amidinophenylalanine-derived matriptase inhibitors Eur.J.Med.Chem., :114437-, 2022 Cited by DOI: 10.1016/j.ejmech.2022.114437PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.12642724334 Å) |
Structure validation
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