6T9V

Bovine Trypsin in complex with the synthetic inhibitor (S)-3-(3-(4-(3-(tert-butyl)ureido)piperidin-1-yl)-2-((3'-fluoro-4'-(hydroxymethyl)-[1,1'-biphenyl])-3-sulfonamido)-3-oxopropyl)benzimidamide (MI-1904)

6T9V の概要

• エントリーDOI: 10.2210/pdb6t9v/pdb
• 分子名称: Cationic Trypsin, trifluoroacetic acid, DIMETHYL SULFOXIDE, ... (6 entities in total)
• 機能のキーワード: trypsine, complex, ligand, hydrolase
• 由来する生物種: Bos taurus
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 26769.34

構造登録者

Merkl, S.,Keils, A.,Mueller, J.M.,Pilgram, O.,Steinmetzer, T. (登録日: 2019-10-28, 公開日: 2020-11-18, 最終更新日: 2024-01-24)

• 主引用文献: Pilgram, O.,Keils, A.,Benary, G.E.,Muller, J.,Merkl, S.,Ngaha, S.,Huber, S.,Chevillard, F.,Harbig, A.,Magdolen, V.,Heine, A.,Bottcher-Friebertshauser, E.,Steinmetzer, T.; Improving the selectivity of 3-amidinophenylalanine-derived matriptase inhibitors; Eur.J.Med.Chem., :114437-, 2022; DOI: 10.1016/j.ejmech.2022.114437

実験手法

X-RAY DIFFRACTION (1.12642724334 Å)