6T95

Trypanothione Reductase from Leismania infantum in complex with 4a

6T95 の概要

• エントリーDOI: 10.2210/pdb6t95/pdb
• 分子名称: Trypanothione reductase, FLAVIN-ADENINE DINUCLEOTIDE, DIMETHYL SULFOXIDE, ... (7 entities in total)
• 機能のキーワード: inhibitor, complex, oxidoreductase, leishmania, drug, flavoprotein
• 由来する生物種: Leishmania infantum
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 55390.36

構造登録者

Carriles, A.A.,Hermoso, J.A. (登録日: 2019-10-25, 公開日: 2020-11-18, 最終更新日: 2024-02-07)

• 主引用文献: de Lucio, H.,Revuelto, A.,Carriles, A.A.,de Castro, S.,Garcia-Gonzalez, S.,Garcia-Soriano, J.C.,Alcon-Calderon, M.,Sanchez-Murcia, P.A.,Hermoso, J.A.,Gago, F.,Camarasa, M.J.,Jimenez-Ruiz, A.,Velazquez, S.; Identification of 1,2,3-triazolium salt-based inhibitors of Leishmania infantum trypanothione disulfide reductase with enhanced antileishmanial potency in cellulo and increased selectivity.; Eur.J.Med.Chem., 244:114878-114878, 2022; PubMed: 36332553; DOI: 10.1016/j.ejmech.2022.114878

実験手法

X-RAY DIFFRACTION (2.5 Å)