6T8M

Prolyl Hydroxylase (PHD) involved in hypoxia sensing by Dictyostelium discoideum

Summary for 6T8M

Entry DOI	10.2210/pdb6t8m/pdb
Descriptor	Prolyl 4-hydroxylase subunit alpha, NICKEL (II) ION, GLYCEROL, ... (6 entities in total)
Functional Keywords	prolyl hydroxylase, oxygen sensing, 2-oxoglutarate and iron dependent oxygenase, oxidoreductase
Biological source	Dictyostelium discoideum
Total number of polymer chains	3
Total formula weight	81967.03
Authors	Chowdhury, R.,McDonough, M.A.,Liu, T.,Clifton, I.J.,Schofield, C.J. (deposition date: 2019-10-24, release date: 2020-09-23, Last modification date: 2024-01-24)
Primary citation	Liu, T.,Abboud, M.I.,Chowdhury, R.,Tumber, A.,Hardy, A.P.,Lippl, K.,Lohans, C.T.,Pires, E.,Wickens, J.,McDonough, M.A.,West, C.M.,Schofield, C.J. Biochemical and biophysical analyses of hypoxia sensing prolyl hydroxylases from Dictyostelium discoideum and Toxoplasma gondii . J.Biol.Chem., 295:16545-16561, 2020 Cited by PubMed: 32934009 DOI: 10.1074/jbc.RA120.013998 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.02 Å)

Structure validation