6T8A

Thrombin in complex with diphenyl ((4-carbamimidoylphenyl)((S)-1-((R)-3-cyclohexyl 2-((phenylmethyl)sulfonamido)propanoyl)pyrrolidine-2-carboxamido)methyl)phosphonate (MI-492)

Summary for 6T8A

• Entry DOI: 10.2210/pdb6t8a/pdb
• Descriptor: Prothrombin, Hirudin variant-2, [(~{R})-(4-carbamimidoylphenyl)-[[(2~{S})-1-[(2~{R})-3-cyclohexyl-2-[(phenylmethyl)sulfonylamino]propanoyl]pyrrolidin-2-yl]carbonylamino]methyl]-phenoxy-phosphinous acid, ... (9 entities in total)
• Functional Keywords: coagulation, blood clotting, convertion of fibrinogen to fibrin, blood clotting inhibitor, thrombin inhibitor, preorganization, glycosylation, blood, hydrolase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 36580.50

Authors

Ngaha, S.A.,Sandner, A.,Huber, S.,Heine, A.,Steinmetzer, T.,Pilgram, O. (deposition date: 2019-10-24, release date: 2020-11-18, Last modification date: 2024-01-24)

• Primary citation: Ngaha, S.A.,Sandner, A.,Huber, S.,Pilgram, O.,Heine, A.,Steinmetzer, T.; Thrombin in complex with diphenyl ((4-carbamimidoylphenyl)((S)-1-((R)-3-cyclohexyl-2-((phenylmethyl)sulfonamido)propanoyl)pyrrolidine-2-carboxamido)methyl)phosphonate (MI-492); to be published,

Experimental method

X-RAY DIFFRACTION (1.62 Å)