6T8A

Thrombin in complex with diphenyl ((4-carbamimidoylphenyl)((S)-1-((R)-3-cyclohexyl 2-((phenylmethyl)sulfonamido)propanoyl)pyrrolidine-2-carboxamido)methyl)phosphonate (MI-492)

6T8A の概要

• エントリーDOI: 10.2210/pdb6t8a/pdb
• 分子名称: Prothrombin, Hirudin variant-2, [(~{R})-(4-carbamimidoylphenyl)-[[(2~{S})-1-[(2~{R})-3-cyclohexyl-2-[(phenylmethyl)sulfonylamino]propanoyl]pyrrolidin-2-yl]carbonylamino]methyl]-phenoxy-phosphinous acid, ... (9 entities in total)
• 機能のキーワード: coagulation, blood clotting, convertion of fibrinogen to fibrin, blood clotting inhibitor, thrombin inhibitor, preorganization, glycosylation, blood, hydrolase
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 36580.50

構造登録者

Ngaha, S.A.,Sandner, A.,Huber, S.,Heine, A.,Steinmetzer, T.,Pilgram, O. (登録日: 2019-10-24, 公開日: 2020-11-18, 最終更新日: 2024-01-24)

• 主引用文献: Ngaha, S.A.,Sandner, A.,Huber, S.,Pilgram, O.,Heine, A.,Steinmetzer, T.; Thrombin in complex with diphenyl ((4-carbamimidoylphenyl)((S)-1-((R)-3-cyclohexyl-2-((phenylmethyl)sulfonamido)propanoyl)pyrrolidine-2-carboxamido)methyl)phosphonate (MI-492); to be published,

実験手法

X-RAY DIFFRACTION (1.62 Å)