6T89

Thrombin in complex with (S)-N-(tert-butyl)-4-(3-(3-carbamimidoylphenyl)-2-((2',4'-dimethoxy-[1,1'-biphenyl])-3-sulfonamido)propanoyl)piperazine-1-carboxamide (MI-498)

6T89 の概要

• エントリーDOI: 10.2210/pdb6t89/pdb
• 分子名称: Prothrombin, Hirudin variant-2, 4-[(2~{S})-3-(3-carbamimidoylphenyl)-2-[[3-(4-methoxy-2-oxidanyl-phenyl)phenyl]sulfonylamino]propanoyl]-~{N}-methyl-piperazine-1-carboxamide, ... (8 entities in total)
• 機能のキーワード: coagulation, blood clotting, convertion of fibrinogen to fibrin, blood clotting inhibitor, thrombin inhibitor, preorganization, glycosylation, blood, hydrolase
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 36365.34

構造登録者

Ngaha, S.A.,Sandner, A.,Huber, S.,Heine, A.,Steinmetzer, T.,Pilgram, O. (登録日: 2019-10-24, 公開日: 2020-11-18, 最終更新日: 2024-01-24)

• 主引用文献: Pilgram, O.,Keils, A.,Benary, G.E.,Muller, J.,Merkl, S.,Ngaha, S.,Huber, S.,Chevillard, F.,Harbig, A.,Magdolen, V.,Heine, A.,Bottcher-Friebertshauser, E.,Steinmetzer, T.; Improving the selectivity of 3-amidinophenylalanine-derived matriptase inhibitors; Eur.J.Med.Chem., :114437-, 2022; DOI: 10.1016/j.ejmech.2022.114437

実験手法

X-RAY DIFFRACTION (2 Å)