6T84

crystal structure of the mycobacterial trehalose monomycolate transport factor A, TtfA

6T84 の概要

• エントリーDOI: 10.2210/pdb6t84/pdb
• 分子名称: Uncharacterized protein, SULFATE ION (3 entities in total)
• 機能のキーワード: trehalose monomycolate, mmpl3 accessory protein, lipid transport
• 由来する生物種: Mycolicibacterium smegmatis MC2 155
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 21609.74

構造登録者

Blaise, M. (登録日: 2019-10-24, 公開日: 2019-12-25, 最終更新日: 2024-05-15)

主引用文献

Ung, K.L.,Alsarraf, H.M.A.B.,Kremer, L.,Blaise, M.
The crystal structure of the mycobacterial trehalose monomycolate transport factor A, TtfA, reveals an atypical fold.
Proteins, 88:809-815, 2020

PubMed Abstract: Trehalose monomycolate (TMM) represents an essential element of the mycobacterial envelope. While synthesized in the cytoplasm, TMM is transported across the inner membrane by MmpL3 but, little is known regarding the MmpL3 partners involved in this process. Recently, the TMM transport factor A (TtfA) was found to form a complex with MmpL3 and to participate in TMM transport, although its biological role remains to be established. Herein, we report the crystal structure of the Mycobacterium smegmatis TtfA core domain. The phylogenetic distribution of TtfA homologues in non-mycolate containing bacteria suggests that TtfA may exert additional functions.

PubMed: 31833106
DOI: 10.1002/prot.25863

実験手法

X-RAY DIFFRACTION (1.4 Å)