6T65
Crsytal structure of Acinetobacter baumannii FabG inhibitor complex at 2.35 A resolution
Summary for 6T65
Entry DOI | 10.2210/pdb6t65/pdb |
Descriptor | 3-oxoacyl-(Acyl-carrier-protein) reductase, ethyl 6-bromanyl-2-[(dimethylamino)methyl]-5-oxidanyl-1-phenyl-indole-3-carboxylate (3 entities in total) |
Functional Keywords | fatty acid biosynthesis, fabg, (3-oxoacyl-(acyl-carrier-protein) reductase), ligand complex, fas-ii, biosynthetic protein |
Biological source | Acinetobacter baumannii |
Total number of polymer chains | 4 |
Total formula weight | 104803.84 |
Authors | Rudraraju, R.,Schnell, R.,Schneider, G. (deposition date: 2019-10-17, release date: 2020-11-18, Last modification date: 2024-01-24) |
Primary citation | Vella, P.,Rudraraju, R.S.,Lundback, T.,Axelsson, H.,Almqvist, H.,Vallin, M.,Schneider, G.,Schnell, R. A FabG inhibitor targeting an allosteric binding site inhibits several orthologs from Gram-negative ESKAPE pathogens. Bioorg.Med.Chem., 30:115898-115898, 2020 Cited by PubMed: 33388594DOI: 10.1016/j.bmc.2020.115898 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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