6T65

Crsytal structure of Acinetobacter baumannii FabG inhibitor complex at 2.35 A resolution

6T65 の概要

• エントリーDOI: 10.2210/pdb6t65/pdb
• 分子名称: 3-oxoacyl-(Acyl-carrier-protein) reductase, ethyl 6-bromanyl-2-[(dimethylamino)methyl]-5-oxidanyl-1-phenyl-indole-3-carboxylate (3 entities in total)
• 機能のキーワード: fatty acid biosynthesis, fabg, (3-oxoacyl-(acyl-carrier-protein) reductase), ligand complex, fas-ii, biosynthetic protein
• 由来する生物種: Acinetobacter baumannii
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 104803.84

構造登録者

Rudraraju, R.,Schnell, R.,Schneider, G. (登録日: 2019-10-17, 公開日: 2020-11-18, 最終更新日: 2024-01-24)

• 主引用文献: Vella, P.,Rudraraju, R.S.,Lundback, T.,Axelsson, H.,Almqvist, H.,Vallin, M.,Schneider, G.,Schnell, R.; A FabG inhibitor targeting an allosteric binding site inhibits several orthologs from Gram-negative ESKAPE pathogens.; Bioorg.Med.Chem., 30:115898-115898, 2020; PubMed: 33388594; DOI: 10.1016/j.bmc.2020.115898

実験手法

X-RAY DIFFRACTION (2.35 Å)