6T3W
Coxsackie B3 2C protein in complex with S-Fluoxetine
Summary for 6T3W
Entry DOI | 10.2210/pdb6t3w/pdb |
Descriptor | 2C protein, ZINC ION, SULFATE ION, ... (6 entities in total) |
Functional Keywords | 2c, enterovirus, helicase, atpase, complex, antiviral, porzac, fluoxetine, repurposing, coxsackievirus, viral protein |
Biological source | Coxsackievirus B3 |
Total number of polymer chains | 1 |
Total formula weight | 24568.33 |
Authors | El Kazzi, P.,Papageorgiou, N.,Ferron, F.P.,Bauer, L.,van Kuppeveld, F.,Coutard, B. (deposition date: 2019-10-11, release date: 2020-11-18, Last modification date: 2024-06-19) |
Primary citation | Hurdiss, D.L.,El Kazzi, P.,Bauer, L.,Papageorgiou, N.,Ferron, F.P.,Donselaar, T.,van Vliet, A.L.W.,Shamorkina, T.M.,Snijder, J.,Canard, B.,Decroly, E.,Brancale, A.,Zeev-Ben-Mordehai, T.,Forster, F.,van Kuppeveld, F.J.M.,Coutard, B. Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes a ring-shaped hexameric complex. Sci Adv, 8:eabj7615-eabj7615, 2022 Cited by PubMed: 34985963DOI: 10.1126/sciadv.abj7615 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.82 Å) |
Structure validation
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