6T35
Crystal structure of AmpC from E.coli with Enmetazobactam (AAI-101)
Summary for 6T35
| Entry DOI | 10.2210/pdb6t35/pdb |
| Descriptor | Beta-lactamase, SULFATE ION, DI(HYDROXYETHYL)ETHER, ... (7 entities in total) |
| Functional Keywords | beta lactamase, antibiotic resistance, antimicrobial protein, mechanism based inhibitor, hydrolase |
| Biological source | Escherichia coli K-12 |
| Total number of polymer chains | 1 |
| Total formula weight | 40461.25 |
| Authors | Lang, P.A.,Leissing, T.M.,Schofield, C.J.,Brem, J. (deposition date: 2019-10-10, release date: 2020-11-18, Last modification date: 2024-03-27) |
| Primary citation | Lang, P.A.,Raj, R.,Tumber, A.,Lohans, C.T.,Rabe, P.,Robinson, C.V.,Brem, J.,Schofield, C.J. Studies on enmetazobactam clarify mechanisms of widely used beta-lactamase inhibitors. Proc.Natl.Acad.Sci.USA, 119:e2117310119-e2117310119, 2022 Cited by PubMed: 35486701DOI: 10.1073/pnas.2117310119 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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