6T2B

Glycoside hydrolase family 109 from Akkermansia muciniphila in complex with GalNAc and NAD+.

Summary for 6T2B

Entry DOI	10.2210/pdb6t2b/pdb
Descriptor	Glycosyl hydrolase family 109 protein 2, 2-acetamido-2-deoxy-alpha-D-galactopyranose, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... (6 entities in total)
Functional Keywords	glycoside hydrolase, inverting, retaining, hydrolase
Biological source	Akkermansia muciniphila
Total number of polymer chains	4
Total formula weight	205981.98
Authors	Chaberski, E.K.,Fredslund, F.,Teze, D.,Shuoker, B.,Kunstmann, S.,Karlsson, E.N.,Hachem, M.A.,Welner, D.H. (deposition date: 2019-10-08, release date: 2020-02-26, Last modification date: 2024-01-24)
Primary citation	Teze, D.,Shuoker, B.,Chaberski, E.K.,Kunstmann, S.,Fredslund, F.,Nielsen, T.S.,Stender, E.G.P.,Peters, G.H.J.,Nordberg Karlsson, E.,Welner, D.H.,Abou Hachem, M. The Catalytic Acid-Base in GH109 Resides in a Conserved GGHGG Loop and Allows for Comparable alpha-Retaining and beta-Inverting Activity in an N-Acetylgalactosaminidase from Akkermansia muciniphila Acs Catalysis, 2020 Cited by DOI: 10.1021/acscatal.9b04474 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.13 Å)

Structure validation