6SZE

RIP2 Kinase Catalytic Domain complex with 5-Amino-1-Phenylpyrazole-4-Carboxamide.

6SZE の概要

• エントリーDOI: 10.2210/pdb6sze/pdb
• 分子名称: Receptor-interacting serine/threonine-protein kinase 2, 5-Amino-1-Phenylpyrazole-4-Carboxamide, CALCIUM ION, ... (4 entities in total)
• 機能のキーワード: fragment based drug design (fbdd), receptor interacting protein 2 kinase, ripk2, rip2k, rip2, structure based drug design (sbdd), transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 71810.46

構造登録者

Convery, M.A.,Charnley, A.K.,Shewchuk, L. (登録日: 2019-10-02, 公開日: 2019-10-23, 最終更新日: 2019-12-04)

• 主引用文献: Haffner, C.D.,Charnley, A.K.,Aquino, C.J.,Casillas, L.,Convery, M.A.,Cox, J.A.,Elban, M.A.,Goodwin, N.C.,Gough, P.J.,Haile, P.A.,Hughes, T.V.,Knapp-Reed, B.,Kreatsoulas, C.,Lakdawala, A.S.,Li, H.,Lian, Y.,Lipshutz, D.,Mehlmann, J.F.,Ouellette, M.,Romano, J.,Shewchuk, L.,Shu, A.,Votta, B.J.,Zhou, H.,Bertin, J.,Marquis, R.W.; Discovery of Pyrazolocarboxamides as Potent and Selective Receptor Interacting Protein 2 (RIP2) Kinase Inhibitors.; Acs Med.Chem.Lett., 10:1518-1523, 2019; PubMed: 31749904; DOI: 10.1021/acsmedchemlett.9b00141

実験手法

X-RAY DIFFRACTION (2.94 Å)