6SWX

Leishmania major methionyl-tRNA synthetase in complex with an allosteric inhibitor

6SWX の概要

• エントリーDOI: 10.2210/pdb6swx/pdb
• 分子名称: Putative methionyl-tRNA synthetase, methyl 2-[[6-[[3,4-bis(fluoranyl)phenyl]amino]-1-methyl-pyrazolo[3,4-d]pyrimidin-4-yl]amino]ethanoate, METHIONINE, ... (4 entities in total)
• 機能のキーワード: leishmania, parasite, aminoacyl-trna synthetase, trna ligase, aars, metrs, methionine, translation, atp-binding, nucleotide-binding, ligase, drug discovery, dundee drug discovery unit
• 由来する生物種: Leishmania major
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 64482.31

構造登録者

Robinson, D.A.,Torrie, L.S.,Shepherd, S.M.,De Rycker, M.,Thomas, M.G.,Wyatt, P.G. (登録日: 2019-09-24, 公開日: 2020-08-05, 最終更新日: 2024-01-24)

• 主引用文献: Torrie, L.S.,Robinson, D.A.,Thomas, M.G.,Hobrath, J.V.,Shepherd, S.M.,Post, J.M.,Ko, E.J.,Ferreira, R.A.,Mackenzie, C.J.,Wrobel, K.,Edwards, D.P.,Gilbert, I.H.,Gray, D.W.,Fairlamb, A.H.,De Rycker, M.; Discovery of an Allosteric Binding Site in Kinetoplastid Methionyl-tRNA Synthetase.; Acs Infect Dis., 6:1044-1057, 2020; PubMed: 32275825; DOI: 10.1021/acsinfecdis.9b00453

実験手法

X-RAY DIFFRACTION (1.95 Å)