6SU0

Crystal structure of dimethylated RSLex in complex with cucurbit[7]uril

6SU0 の概要

• エントリーDOI: 10.2210/pdb6su0/pdb
• 分子名称: Fucose-binding lectin protein, SODIUM ION, cucurbit[7]uril, ... (5 entities in total)
• 機能のキーワード: cucurbituril, molecular glue, crystal engineering, sugar binding protein
• 由来する生物種: Ralstonia solanacearum
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 134405.46

構造登録者

Guagnini, F.,Engilberge, S.,Crowley, P.B. (登録日: 2019-09-12, 公開日: 2020-02-19, 最終更新日: 2024-01-24)

主引用文献

Guagnini, F.,Engilberge, S.,Ramberg, K.O.,Perez, J.,Crowley, P.B.
Engineered assembly of a protein-cucurbituril biohybrid.
Chem.Commun.(Camb.), 56:360-363, 2020

PubMed Abstract: A crystalline biohybrid with a 4 : 1 protein : cucurbituril mass ratio is presented. This result was achieved by engineering additional cucurbit[7]uril (Q7) binding sites into a β-propeller protein. In contrast to the parent protein, Q7-controlled assembly of the engineered variant occurred in solution, as evidenced by NMR and SAXS measurements.

PubMed: 31825399
DOI: 10.1039/c9cc07198a

実験手法

X-RAY DIFFRACTION (1.98 Å)