6SSJ
Human endogenous retrovirus (HML2) mature capsid assembly, T=1 icosahedron
6SSJ の概要
エントリーDOI | 10.2210/pdb6ssj/pdb |
EMDBエントリー | 10295 10296 10297 10298 |
分子名称 | Endogenous retrovirus group K member 24 Gag polyprotein (1 entity in total) |
機能のキーワード | mature retrovirus capsid assembly, viral protein |
由来する生物種 | Homo sapiens (Human) |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 27570.49 |
構造登録者 | |
主引用文献 | Acton, O.,Grant, T.,Nicastro, G.,Ball, N.J.,Goldstone, D.C.,Robertson, L.E.,Sader, K.,Nans, A.,Ramos, A.,Stoye, J.P.,Taylor, I.A.,Rosenthal, P.B. Structural basis for Fullerene geometry in a human endogenous retrovirus capsid. Nat Commun, 10:5822-5822, 2019 Cited by PubMed Abstract: The HML2 (HERV-K) group constitutes the most recently acquired family of human endogenous retroviruses, with many proviruses less than one million years old. Many maintain intact open reading frames and provirus expression together with HML2 particle formation are observed in early stage human embryo development and are associated with pluripotency as well as inflammatory disease, cancers and HIV-1 infection. Here, we reconstruct the core structural protein (CA) of an HML2 retrovirus, assemble particles in vitro and employ single particle cryogenic electron microscopy (cryo-EM) to determine structures of four classes of CA Fullerene shell assemblies. These icosahedral and capsular assemblies reveal at high-resolution the molecular interactions that allow CA to form both pentamers and hexamers and show how invariant pentamers and structurally plastic hexamers associate to form the unique polyhedral structures found in retroviral cores. PubMed: 31862888DOI: 10.1038/s41467-019-13786-y 主引用文献が同じPDBエントリー |
実験手法 | ELECTRON MICROSCOPY (2.75 Å) |
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