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6SSJ

Human endogenous retrovirus (HML2) mature capsid assembly, T=1 icosahedron

6SSJ の概要
エントリーDOI10.2210/pdb6ssj/pdb
EMDBエントリー10295 10296 10297 10298
分子名称Endogenous retrovirus group K member 24 Gag polyprotein (1 entity in total)
機能のキーワードmature retrovirus capsid assembly, viral protein
由来する生物種Homo sapiens (Human)
タンパク質・核酸の鎖数1
化学式量合計27570.49
構造登録者
Acton, O.J.H.,Taylor, I.A.,Rosenthal, P.B. (登録日: 2019-09-08, 公開日: 2020-01-01, 最終更新日: 2024-05-22)
主引用文献Acton, O.,Grant, T.,Nicastro, G.,Ball, N.J.,Goldstone, D.C.,Robertson, L.E.,Sader, K.,Nans, A.,Ramos, A.,Stoye, J.P.,Taylor, I.A.,Rosenthal, P.B.
Structural basis for Fullerene geometry in a human endogenous retrovirus capsid.
Nat Commun, 10:5822-5822, 2019
Cited by
PubMed Abstract: The HML2 (HERV-K) group constitutes the most recently acquired family of human endogenous retroviruses, with many proviruses less than one million years old. Many maintain intact open reading frames and provirus expression together with HML2 particle formation are observed in early stage human embryo development and are associated with pluripotency as well as inflammatory disease, cancers and HIV-1 infection. Here, we reconstruct the core structural protein (CA) of an HML2 retrovirus, assemble particles in vitro and employ single particle cryogenic electron microscopy (cryo-EM) to determine structures of four classes of CA Fullerene shell assemblies. These icosahedral and capsular assemblies reveal at high-resolution the molecular interactions that allow CA to form both pentamers and hexamers and show how invariant pentamers and structurally plastic hexamers associate to form the unique polyhedral structures found in retroviral cores.
PubMed: 31862888
DOI: 10.1038/s41467-019-13786-y
主引用文献が同じPDBエントリー
実験手法
ELECTRON MICROSCOPY (2.75 Å)
構造検証レポート
Validation report summary of 6ssj
検証レポート(詳細版)ダウンロードをダウンロード

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件を2025-07-09に公開中

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