6SSF

Transaminase with LCS bound

Summary for 6SSF

Entry DOI	10.2210/pdb6ssf/pdb
Descriptor	ForI-LCS, SULFATE ION, [4-[(~{Z})-[(2~{S},5~{S})-5-(azanyloxymethyl)-3,6-bis(oxidanylidene)piperazin-2-yl]methoxyiminomethyl]-6-methyl-5-oxidanyl-pyridin-3-yl]methyl dihydrogen phosphate, ... (4 entities in total)
Functional Keywords	lcs bound, transferase
Biological source	Streptomyces kaniharaensis
Total number of polymer chains	2
Total formula weight	90553.48
Authors	Naismith, J.H.,Gao, S. (deposition date: 2019-09-06, release date: 2020-01-15, Last modification date: 2024-05-15)
Primary citation	Gao, S.,Liu, H.,de Crecy-Lagard, V.,Zhu, W.,Richards, N.G.J.,Naismith, J.H. PMP-diketopiperazine adducts form at the active site of a PLP dependent enzyme involved in formycin biosynthesis. Chem.Commun.(Camb.), 55:14502-14505, 2019 Cited by PubMed Abstract: ForI is a PLP-dependent enzyme from the biosynthetic pathway of the C-nucleoside antibiotic formycin. Cycloserine is thought to inhibit PLP-dependent enzymes by irreversibly forming a PMP-isoxazole. We now report that ForI forms novel PMP-diketopiperazine derivatives following incubation with both d and l cycloserine. This unexpected result suggests chemical diversity in the chemistry of cycloserine inhibition. PubMed: 31730149 DOI: 10.1039/c9cc06975e PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.48 Å)

Structure validation