6SSF

Transaminase with LCS bound

6SSF の概要

• エントリーDOI: 10.2210/pdb6ssf/pdb
• 分子名称: ForI-LCS, SULFATE ION, [4-[(~{Z})-[(2~{S},5~{S})-5-(azanyloxymethyl)-3,6-bis(oxidanylidene)piperazin-2-yl]methoxyiminomethyl]-6-methyl-5-oxidanyl-pyridin-3-yl]methyl dihydrogen phosphate, ... (4 entities in total)
• 機能のキーワード: lcs bound, transferase
• 由来する生物種: Streptomyces kaniharaensis
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 90553.48

構造登録者

Naismith, J.H.,Gao, S. (登録日: 2019-09-06, 公開日: 2020-01-15, 最終更新日: 2024-05-15)

主引用文献

Gao, S.,Liu, H.,de Crecy-Lagard, V.,Zhu, W.,Richards, N.G.J.,Naismith, J.H.
PMP-diketopiperazine adducts form at the active site of a PLP dependent enzyme involved in formycin biosynthesis.
Chem.Commun.(Camb.), 55:14502-14505, 2019

PubMed Abstract: ForI is a PLP-dependent enzyme from the biosynthetic pathway of the C-nucleoside antibiotic formycin. Cycloserine is thought to inhibit PLP-dependent enzymes by irreversibly forming a PMP-isoxazole. We now report that ForI forms novel PMP-diketopiperazine derivatives following incubation with both d and l cycloserine. This unexpected result suggests chemical diversity in the chemistry of cycloserine inhibition.

PubMed: 31730149
DOI: 10.1039/c9cc06975e

実験手法

X-RAY DIFFRACTION (1.48 Å)