6SSD
Transaminase with PLP bound
Summary for 6SSD
| Entry DOI | 10.2210/pdb6ssd/pdb |
| Descriptor | ForI-PLP, PYRIDOXAL-5'-PHOSPHATE, SULFATE ION, ... (4 entities in total) |
| Functional Keywords | plp bound, transferase |
| Biological source | Streptomyces kaniharaensis |
| Total number of polymer chains | 1 |
| Total formula weight | 44898.45 |
| Authors | Naismith, J.H.,Gao, S. (deposition date: 2019-09-06, release date: 2020-01-15, Last modification date: 2025-04-09) |
| Primary citation | Gao, S.,Liu, H.,de Crecy-Lagard, V.,Zhu, W.,Richards, N.G.J.,Naismith, J.H. PMP-diketopiperazine adducts form at the active site of a PLP dependent enzyme involved in formycin biosynthesis. Chem.Commun.(Camb.), 55:14502-14505, 2019 Cited by PubMed Abstract: ForI is a PLP-dependent enzyme from the biosynthetic pathway of the C-nucleoside antibiotic formycin. Cycloserine is thought to inhibit PLP-dependent enzymes by irreversibly forming a PMP-isoxazole. We now report that ForI forms novel PMP-diketopiperazine derivatives following incubation with both d and l cycloserine. This unexpected result suggests chemical diversity in the chemistry of cycloserine inhibition. PubMed: 31730149DOI: 10.1039/c9cc06975e PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.18 Å) |
Structure validation
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