6SSD

Transaminase with PLP bound

6SSD の概要

• エントリーDOI: 10.2210/pdb6ssd/pdb
• 分子名称: ForI-PLP, PYRIDOXAL-5'-PHOSPHATE, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: plp bound, transferase
• 由来する生物種: Streptomyces kaniharaensis
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 44898.45

構造登録者

Naismith, J.H.,Gao, S. (登録日: 2019-09-06, 公開日: 2020-01-15, 最終更新日: 2025-04-09)

主引用文献

Gao, S.,Liu, H.,de Crecy-Lagard, V.,Zhu, W.,Richards, N.G.J.,Naismith, J.H.
PMP-diketopiperazine adducts form at the active site of a PLP dependent enzyme involved in formycin biosynthesis.
Chem.Commun.(Camb.), 55:14502-14505, 2019

PubMed Abstract: ForI is a PLP-dependent enzyme from the biosynthetic pathway of the C-nucleoside antibiotic formycin. Cycloserine is thought to inhibit PLP-dependent enzymes by irreversibly forming a PMP-isoxazole. We now report that ForI forms novel PMP-diketopiperazine derivatives following incubation with both d and l cycloserine. This unexpected result suggests chemical diversity in the chemistry of cycloserine inhibition.

PubMed: 31730149
DOI: 10.1039/c9cc06975e

実験手法

X-RAY DIFFRACTION (1.18 Å)