6SNB

Structure of Coxsackievirus A10 A-particle

Summary for 6SNB

• Entry DOI: 10.2210/pdb6snb/pdb
• Related: 6SMG
• EMDB information: 10256
• Descriptor: Capsid protein VP1, Capsid protein VP2, Capsid protein VP3 (3 entities in total)
• Functional Keywords: cv-a10, kremen1, virus-receptor complex, hand, foot and mouth disease, virus, picornavirus uncoating intermediate
• Biological source: Coxsackievirus A10; More
• Total number of polymer chains: 3
• Total formula weight: 87141.07

Authors

Zhao, Y.,Zhou, D.,Ni, T.,Karia, D.,Kotecha, A.,Wang, X.,Rao, Z.,Jones, E.Y.,Fry, E.E.,Ren, J.,Stuart, D.I. (deposition date: 2019-08-23, release date: 2020-01-15, Last modification date: 2024-05-22)

Primary citation

Zhao, Y.,Zhou, D.,Ni, T.,Karia, D.,Kotecha, A.,Wang, X.,Rao, Z.,Jones, E.Y.,Fry, E.E.,Ren, J.,Stuart, D.I.
Hand-foot-and-mouth disease virus receptor KREMEN1 binds the canyon of Coxsackie Virus A10.
Nat Commun, 11:38-38, 2020

PubMed Abstract: Coxsackievirus A10 (CV-A10) is responsible for an escalating number of severe infections in children, but no prophylactics or therapeutics are currently available. KREMEN1 (KRM1) is the entry receptor for the largest receptor-group of hand-foot-and-mouth disease causing viruses, which includes CV-A10. We report here structures of CV-A10 mature virus alone and in complex with KRM1 as well as of the CV-A10 A-particle. The receptor spans the viral canyon with a large footprint on the virus surface. The footprint has some overlap with that seen for the neonatal Fc receptor complexed with enterovirus E6 but is larger and distinct from that of another enterovirus receptor SCARB2. Reduced occupancy of a particle-stabilising pocket factor in the complexed virus and the presence of both unbound and expanded virus particles suggests receptor binding initiates a cascade of conformational changes that produces expanded particles primed for viral uncoating.

PubMed: 31911601
DOI: 10.1038/s41467-019-13936-2

Experimental method

ELECTRON MICROSCOPY (4.4 Å)