6SM1

Wild type immunoglobulin light chain (WT-1)

Summary for 6SM1

• Entry DOI: 10.2210/pdb6sm1/pdb
• Related: 4nki
• Descriptor: Immunoglobulin lambda variable 2-14, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... (5 entities in total)
• Functional Keywords: al amyloidosis, antibody folding, protein stability, dynamics, immune system
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 12371.54

Authors

Kazman, P.,Vielberg, M.-T.,Cendales, M.D.P.,Hunziger, L.,Weber, B.,Hegenbart, U.,Zacharias, M.,Koehler, R.,Schoenland, S.,Groll, M.,Buchner, J. (deposition date: 2019-08-21, release date: 2020-03-18, Last modification date: 2024-01-24)

• Primary citation: Kazman, P.,Vielberg, M.T.,Pulido Cendales, M.D.,Hunziger, L.,Weber, B.,Hegenbart, U.,Zacharias, M.,Kohler, R.,Schonland, S.,Groll, M.,Buchner, J.; Fatal amyloid formation in a patient's antibody light chain is caused by a single point mutation.; Elife, 9:-, 2020; PubMed: 32151314; DOI: 10.7554/eLife.52300

Experimental method

X-RAY DIFFRACTION (1.55 Å)