6SLW

Fragment AZ-004 binding at the TAZpS89/14-3-3 sigma interface

6SLW の概要

• エントリーDOI: 10.2210/pdb6slw/pdb
• 分子名称: 14-3-3 protein sigma, WW domain-containing transcription regulator protein 1, 4-methyl-5-phenyl-thiophene-2-carboximidamide, ... (4 entities in total)
• 機能のキーワード: protein protein interaction, fragment soaking, stabilization, peptide binding protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 30065.56

構造登録者

Ottmann, C.,Wolter, M.,Guillory, X.,Leysen, S.,Genet, S.,Somsen, B.,Patel, J.,Castaldi, P. (登録日: 2019-08-20, 公開日: 2020-06-17, 最終更新日: 2024-01-24)

• 主引用文献: Guillory, X.,Wolter, M.,Leysen, S.,Neves, J.F.,Kuusk, A.,Genet, S.,Somsen, B.,Morrow, J.K.,Rivers, E.,van Beek, L.,Patel, J.,Goodnow, R.,Schoenherr, H.,Fuller, N.,Cao, Q.,Doveston, R.G.,Brunsveld, L.,Arkin, M.R.,Castaldi, P.,Boyd, H.,Landrieu, I.,Chen, H.,Ottmann, C.; Fragment-based Differential Targeting of PPI Stabilizer Interfaces.; J.Med.Chem., 63:6694-6707, 2020; PubMed: 32501690; DOI: 10.1021/acs.jmedchem.9b01942

実験手法

X-RAY DIFFRACTION (2 Å)