6SI3

p53 cancer mutant Y220S in complex with small-molecule stabilizer PK9301

Summary for 6SI3

Entry DOI	10.2210/pdb6si3/pdb
Descriptor	Cellular tumor antigen p53, ZINC ION, 1-[7-bromanyl-9-[2,2,2-tris(fluoranyl)ethyl]carbazol-3-yl]-~{N}-methyl-methanamine, ... (6 entities in total)
Functional Keywords	p53, transcription factor, tumor suppressor, cancer therapy, oncogenic mutant, protein misfolding, dna-binding domain, druggable surface crevice, small-molecule stabilizer, mutant p53 rescue, dna binding protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	50181.00
Authors	Joerger, A.C.,Bauer, M.R.,Structural Genomics Consortium (SGC) (deposition date: 2019-08-08, release date: 2020-02-19, Last modification date: 2024-01-24)
Primary citation	Bauer, M.R.,Kramer, A.,Settanni, G.,Jones, R.N.,Ni, X.,Khan Tareque, R.,Fersht, A.R.,Spencer, J.,Joerger, A.C. Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm. Acs Chem.Biol., 15:657-668, 2020 Cited by PubMed: 31990523 DOI: 10.1021/acschembio.9b00748 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.4 Å)

Structure validation