6SI3

p53 cancer mutant Y220S in complex with small-molecule stabilizer PK9301

6SI3 の概要

• エントリーDOI: 10.2210/pdb6si3/pdb
• 分子名称: Cellular tumor antigen p53, ZINC ION, 1-[7-bromanyl-9-[2,2,2-tris(fluoranyl)ethyl]carbazol-3-yl]-~{N}-methyl-methanamine, ... (6 entities in total)
• 機能のキーワード: p53, transcription factor, tumor suppressor, cancer therapy, oncogenic mutant, protein misfolding, dna-binding domain, druggable surface crevice, small-molecule stabilizer, mutant p53 rescue, dna binding protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 50181.00

構造登録者

Joerger, A.C.,Bauer, M.R.,Structural Genomics Consortium (SGC) (登録日: 2019-08-08, 公開日: 2020-02-19, 最終更新日: 2024-01-24)

• 主引用文献: Bauer, M.R.,Kramer, A.,Settanni, G.,Jones, R.N.,Ni, X.,Khan Tareque, R.,Fersht, A.R.,Spencer, J.,Joerger, A.C.; Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm.; Acs Chem.Biol., 15:657-668, 2020; PubMed: 31990523; DOI: 10.1021/acschembio.9b00748

実験手法

X-RAY DIFFRACTION (1.4 Å)