6SI1

p53 cancer mutant Y220H

Summary for 6SI1

• Entry DOI: 10.2210/pdb6si1/pdb
• Descriptor: Cellular tumor antigen p53, ZINC ION, 1,2-ETHANEDIOL, ... (6 entities in total)
• Functional Keywords: p53, transcription factor, tumor suppressor, cancer therapy, oncogenic mutant, protein misfolding, dna-binding domain, mutant p53 rescue, structural genomics, structural genomics consortium, sgc, dna binding protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 49747.01

Authors

Joerger, A.C.,Kraemer, A.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2019-08-08, release date: 2020-02-19, Last modification date: 2024-01-24)

• Primary citation: Bauer, M.R.,Kramer, A.,Settanni, G.,Jones, R.N.,Ni, X.,Khan Tareque, R.,Fersht, A.R.,Spencer, J.,Joerger, A.C.; Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm.; Acs Chem.Biol., 15:657-668, 2020; PubMed: 31990523; DOI: 10.1021/acschembio.9b00748

Experimental method

X-RAY DIFFRACTION (1.44 Å)