6SGH

Nek2 kinase covalently bound to 2-arylamino-6-ethynylpurine inhibitor 66

6SGH の概要

• エントリーDOI: 10.2210/pdb6sgh/pdb
• 分子名称: Serine/threonine-protein kinase Nek2, 2-[4-[(6-ethenyl-9~{H}-purin-2-yl)amino]phenyl]ethanamide (3 entities in total)
• 機能のキーワード: "covalent inhibitor" kinase, cell cycle
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 32956.79

構造登録者

Richards, M.W.,Mas-Droux, C.P.,Bayliss, R. (登録日: 2019-08-04, 公開日: 2020-06-17, 最終更新日: 2024-01-24)

• 主引用文献: Matheson, C.J.,Coxon, C.R.,Bayliss, R.,Boxall, K.,Carbain, B.,Fry, A.M.,Hardcastle, I.R.,Harnor, S.J.,Mas-Droux, C.,Newell, D.R.,Richards, M.W.,Sivaprakasam, M.,Turner, D.,Griffin, R.J.,Golding, B.T.,Cano, C.; 2-Arylamino-6-ethynylpurines are cysteine-targeting irreversible inhibitors of Nek2 kinase.; Rsc Med Chem, 11:707-731, 2020; PubMed: 33479670; DOI: 10.1039/d0md00074d

実験手法

X-RAY DIFFRACTION (3 Å)