6SE4

Crystal Structure of the first bromodomain of human BRD4 in complex with (+)-JD1, an Organometallic BET Bromodomain Inhibitor

Summary for 6SE4

• Entry DOI: 10.2210/pdb6se4/pdb
• Descriptor: Bromodomain-containing protein 4, 1,2-ETHANEDIOL, (+)-JD1, ... (5 entities in total)
• Functional Keywords: bromodomain-containing protein 4 isoform long, brd4, bromodomain, organometallic bet bromodomain inhibitor, structural genomics, structural genomics consortium, sgc, protein binding
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 15954.62

Authors

Krojer, T.,Hassell-Hart, S.,Picaud, S.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Filippakopoulos, P.,Spencer, J.,von Delft, F.,Structural Genomics Consortium (SGC) (deposition date: 2019-07-29, release date: 2019-08-14, Last modification date: 2024-01-24)

• Primary citation: Krojer, T.,Hassell-Hart, S.,Picaud, S.,Filippakopoulos, P.,Spencer, J.,von Delft, F.; Crystal Structure of the first bromodomain of human BRD4 in complex with (+)-JD1, an Organometallic BET Bromodomain Inhibitor; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.38 Å)