6SE4

Crystal Structure of the first bromodomain of human BRD4 in complex with (+)-JD1, an Organometallic BET Bromodomain Inhibitor

6SE4 の概要

• エントリーDOI: 10.2210/pdb6se4/pdb
• 分子名称: Bromodomain-containing protein 4, 1,2-ETHANEDIOL, (+)-JD1, ... (5 entities in total)
• 機能のキーワード: bromodomain-containing protein 4 isoform long, brd4, bromodomain, organometallic bet bromodomain inhibitor, structural genomics, structural genomics consortium, sgc, protein binding
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15954.62

構造登録者

Krojer, T.,Hassell-Hart, S.,Picaud, S.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Filippakopoulos, P.,Spencer, J.,von Delft, F.,Structural Genomics Consortium (SGC) (登録日: 2019-07-29, 公開日: 2019-08-14, 最終更新日: 2024-01-24)

• 主引用文献: Krojer, T.,Hassell-Hart, S.,Picaud, S.,Filippakopoulos, P.,Spencer, J.,von Delft, F.; Crystal Structure of the first bromodomain of human BRD4 in complex with (+)-JD1, an Organometallic BET Bromodomain Inhibitor; To Be Published,

実験手法

X-RAY DIFFRACTION (1.38 Å)