6SBT

Structure of GluK1 ligand-binding domain (S1S2) in complex with N-(7-(1H-imidazol-1-yl)-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl benzamide at 2.3 A resolution

Summary for 6SBT

• Entry DOI: 10.2210/pdb6sbt/pdb
• Descriptor: Glutamate receptor ionotropic, kainate 1, SULFATE ION, ~{N}-[7-imidazol-1-yl-2,3-bis(oxidanylidene)-6-(trifluoromethyl)-4~{H}-quinoxalin-1-yl]benzamide, ... (6 entities in total)
• Functional Keywords: kainate receptor ligand-binding domain, gluk1-s1s2, antagonist, membrane protein
• Biological source: Rattus norvegicus (Rat); More
• Total number of polymer chains: 1
• Total formula weight: 29971.00

Authors

Moellerud, S.,Frydenvang, K.,Kastrup, J.S. (deposition date: 2019-07-22, release date: 2019-10-30, Last modification date: 2024-01-24)

• Primary citation: Mollerud, S.,Hansen, R.B.,Pallesen, J.,Temperini, P.,Pasini, D.,Bornholt, J.,Nielsen, B.,Mamedova, E.,Chalupnik, P.,Paternain, A.V.,Lerma, J.,Diaz-delCastillo, M.,Andreasen, J.T.,Frydenvang, K.,Kastrup, J.S.,Johansen, T.N.,Pickering, D.S.; N-(7-(1H-Imidazol-1-yl)-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl)benzamide, a New Kainate Receptor Selective Antagonist and Analgesic: Synthesis, X-ray Crystallography, Structure-Affinity Relationships, and in Vitro and in Vivo Pharmacology.; Acs Chem Neurosci, 10:4685-4695, 2019; PubMed: 31622082; DOI: 10.1021/acschemneuro.9b00479

Experimental method

X-RAY DIFFRACTION (2.3 Å)