6SBR

The crystal structure of PfA-M1 in complex with 7-amino-1,4-dibromo-5,7,8,9-tetrahydrobenzocyclohepten-6-one

6SBR の概要

• エントリーDOI: 10.2210/pdb6sbr/pdb
• 分子名称: M1-family alanyl aminopeptidase, ZINC ION, [(7~{S})-1,4-bis(bromanyl)-6,6-bis(oxidanyl)-5,7,8,9-tetrahydrobenzo[7]annulen-7-yl]azanium, ... (7 entities in total)
• 機能のキーワード: m1 aminopeptidase, hydrolase
• 由来する生物種: Plasmodium falciparum (isolate 3D7)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 108445.09

構造登録者

Salomon, E.,Schmitt, M.,Mouray, E.,McEwen, A.G.,Torchy, M.,Poussin-Courmontagne, P.,Alavi, S.,Tarnus, C.,Cavarelli, J.,Florent, I.,Albrecht, S. (登録日: 2019-07-22, 公開日: 2020-03-25, 最終更新日: 2024-01-24)

• 主引用文献: Salomon, E.,Schmitt, M.,Mouray, E.,McEwen, A.G.,Bounaadja, L.,Torchy, M.,Poussin-Courmontagne, P.,Alavi, S.,Tarnus, C.,Cavarelli, J.,Florent, I.,Albrecht, S.; Aminobenzosuberone derivatives as PfA-M1 inhibitors: Molecular recognition and antiplasmodial evaluation.; Bioorg.Chem., 98:103750-103750, 2020; PubMed: 32182520; DOI: 10.1016/j.bioorg.2020.103750

実験手法

X-RAY DIFFRACTION (1.54 Å)