6S9W
Crystal Structure of AKT1 in Complex with Covalent-Allosteric AKT Inhibitor 16a
Summary for 6S9W
Entry DOI | 10.2210/pdb6s9w/pdb |
Descriptor | RAC-alpha serine/threonine-protein kinase, ~{N}-[3-[1-[[4-(5-methyl-6-oxidanylidene-3-phenyl-1~{H}-pyrazin-2-yl)phenyl]methyl]piperidin-4-yl]-2-oxidanylidene-1~{H}-benzimidazol-5-yl]propanamide (3 entities in total) |
Functional Keywords | akt1, akt2, akt3, borussertib, covalent-allosteric, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 52308.70 |
Authors | Landel, I.,Mueller, M.P.,Rauh, D. (deposition date: 2019-07-15, release date: 2019-10-16, Last modification date: 2024-01-24) |
Primary citation | Quambusch, L.,Landel, I.,Depta, L.,Weisner, J.,Uhlenbrock, N.,Muller, M.P.,Glanemann, F.,Althoff, K.,Siveke, J.T.,Rauh, D. Covalent-Allosteric Inhibitors to Achieve Akt Isoform-Selectivity. Angew.Chem.Int.Ed.Engl., 58:18823-18829, 2019 Cited by PubMed: 31584233DOI: 10.1002/anie.201909857 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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