6S70

Crystal structure of CARM1 in complex with inhibitor UM251

6S70 の概要

• エントリーDOI: 10.2210/pdb6s70/pdb
• 分子名称: Histone-arginine methyltransferase CARM1, 1-[5-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-(3-azanylpropyl)amino]pentyl]guanidine, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: inhibitor, complex, arginine methyltransferase, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 162172.37

構造登録者

Gunnell, E.A.,Muhsen, U.,Dowden, J.,Dreveny, I. (登録日: 2019-07-04, 公開日: 2020-03-04, 最終更新日: 2024-05-15)

• 主引用文献: Gunnell, E.A.,Al-Noori, A.,Muhsen, U.,Davies, C.C.,Dowden, J.,Dreveny, I.; Structural and biochemical evaluation of bisubstrate inhibitors of protein arginine N-methyltransferases PRMT1 and CARM1 (PRMT4).; Biochem.J., 477:787-800, 2020; PubMed: 32011657; DOI: 10.1042/BCJ20190826

実験手法

X-RAY DIFFRACTION (2.3 Å)